Abstract
Abstract Bioinformatics, a multidisciplinary field works in collaboration with biological sciences for analysis, prediction and storage of biological data in form of databases. In innovative world of scientific technology, Pakistan is playing its crucial role in development of new era of e-science. Main objective of this review is to highlight bioinformatics applications and its significant role in progress of e-science in Pakistan. In Pakistan, numerous applications such as gene target approaches in agriculture, food industries and 3-dimensional structure analysis of protein have been revealed, where every aspect of nucleic acids processing can be observed. With these advancements, disease diagnosis has now become easy, providing a platform for drug development and enormous jobs for talented ones to make a history in bioinformatics. Similarly, numerous organizations are also taking part in Next Generation Sequencing (NGS) technology and different nationwide companies. However, bioinformatics also faces challenges in data collection and web designing. But introduction of innovative researches has led to formation of highly applicable e-technology of recent era. Hence, this approach has taken primacy to diagnose diseases as cancer. It makes a tremendous distinction in e-science where computer-aided drug design (CADD) gives a ray of hope for many diseased people. Moreover, comprehensive study of human genetics also reveals invention of specified drugs and various biomarkers to discriminate among every single genetic disease. Regardless of various hurdles, scientific transformations in very field related to bioinformatics will help us to take Pakistan beyond skylines and to stand with high tech world association. Keywords: Computational tools; Disease management; E-science in Pakistan; In-Silico approaches; Life sciences; NGS technology http://dx.doi.org/10.19045/bspab.2019.80004
Highlights
Bioinformatics, a multidisciplinary field works in collaboration with biological sciences for analysis, prediction and storage of biological data in form of databases
Disease diagnosis has become easy, providing a platform for drug development and enormous jobs for talented ones to make a history in bioinformatics
Small dimension in Pakistan is working on this aspect but near future possibilities declare the value of bioinformatics in different research projects
Summary
Nucleotide Polymorphisms (SNPs) which are responsible for genetic disorders like. Pakistan, the pharmaceutical industry is widely spread Bioinformatics helps out to design and develop new drug candidates and techniques to identify and eradicate novel diseases. Protein LPAR6 is responsible for a hair loss disease called hypotrichosis, is analysed by various bioinformatics approaches e.g. Ensemble Genome Browser (http://www.ensembl.org) for determination of primary structure and MODELLER 9V8 tool for 3D analysis [26, 27]. Bioinformatics and health care development The enormous amount of available proteomics and genomics data provides us an opportunity to develop novel therapeutic approaches and research methodologies for disease prevention and treatment. This goal can’t be achieved without effective data management and integrating it with clinical and medical records.
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