Abstract
The emergence of carbapenemase-producing Klebsiella pneumoniae (CPKP) has become a great concern worldwide. In this study, 994 non-duplicate, carbapenem non-susceptible Klebsiella pneumonia isolates were collected in Taiwan from 2011 to 2013 for detection of the carbapenemase genes, assessment of antimicrobial susceptibility and molecular epidemiology studies. Of these 994 isolates, 183 (18.4%) had carbapenemase genes: 157 (15.8%) KPC (145 KPC-2 and 12 KPC-17), 16 (1.6%) IMP-8, 9 (0.9%) VIM-1, and 1 (0.1%) NDM-1. KPC had the highest prevalence rate among the carbapenemases and represented a major epidemic clone circulating in Taiwan. The ST512 and ST258 KPC-2 KPs were first identified in Taiwan and were grouped into a small cluster in the PFGE profile. In addition, the genetic structure encompassing the bla KPC gene of the ST512 and ST258 isolates showed a different pattern from that of other KPC isolates. ST11 may be a major sequence type circulating in Taiwan, although a specific minor clone has begun to be observed. This is the first report of ST258 and ST512 KPC-2 KP isolates in Taiwan, whether ST258 and ST512 will become the next endemic problems in Taiwan should be closely monitored.
Highlights
The emergence and global spread of carbapenemase-producing Enterobacteriaeae (CPE) is of great concern to health services worldwide [1,2,3]
Had carbapenemase genes detected from the following groups: 157 (15.8%) from KPC (145 from KPC-2 and 12 from KPC-17), 16 (1.6%) from IMP-8, 9 (0.9%) from VIM-1, and 1 (0.1%)
The first reported carbapenemase-producing Klebsiella pneumoniae (CPKP) outbreak detected in Taiwan was caused by IMP-8 Klebsiella pneumonia (KP) through 1999 to 2000 [18]
Summary
The emergence and global spread of carbapenemase-producing Enterobacteriaeae (CPE) is of great concern to health services worldwide [1,2,3]. Carbapenemase- producing Klebsiella pneumoniae (CPKP) has rapidly emerged as one of the major nosocomial pathogens among CPE [4, 5]. Spreading of KPC-2 and KPC-17 Producing Klebsiella Pneumonia in Taiwan lactamases (IMP, VIM, GIM, SPM, NDM) and class D beta-lactamases (OXA) [7]. These carbapenemases have emerged in various parts of the world, including Europe, the US, the Indian subcontinent, and eastern countries. Klebsiella pneumoniae with KPC carbapenemase was first detected in 1996 in the US and subsequently spread worldwide [8,9,10]. The high prevalence of CPKP makes it necessary to investigate resistance epidemiology in each country to combat further spread
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