EMBRYOLOGICAL PREREQUISITES FOR HUMAN CRANIAL DEVELOPMENTAL DEFFECTS

Abstract

The purpose of the work is to find out the embryological prerequisites and the time of the possible occurrence of malformations and congenital deformations of the human skull.Results. The growth and enlargement of the neurocranium is largely determined by the growth of the brain due to their close syntopy. By the end of the second year, the bones are connected by sutures. The neurocranium is embryologically divided into the vault, which is formed by membranous ossification, and the basis cranii, the bones of which are formed by cartilaginous osteogenesis. The initial development of the neurocranium depends on the formation of the brain and its surrounding membranes. The source of the germ of the outer layer is the mesoderm and ectomesenchyme of the neural crest, soon it is divided into the inner layer – endomeninx and outer – ectomeninx. The latter is further divided into the outer osteogenic layer, in which the ossification centers form the bones of the skull, and the inner layer of the dura mater. The centers of ossification form the frontal, parietal, occipital and temporal bones, and the intermediate areas form fibrous sutures and fontanelles. Usually, the sutures are joined at the end of the second year of life. Conclusions. Congenital deformities of the cerebral part of the skull are morphological manifestations of numerous hereditary syndromes and/or metabolic, teratogenic effects, lysosomal storage diseases, brain malformations, unfavorable factors during the fetal period of development: restriction of the intrauterine environment, weak muscle tone, torticollis, clavicle fracture, cervical spine anomalies, multiple pregnancy and bone mineralization disorders. For the differential diagnosis of congenital defects of the skull, along with the use of diagnostic three-dimensional medical imaging, it is necessary to carry out genetic screening.