Abstract
Comparative researches of borderline between telencephalon neuroepithelium and its surrounding mesenchyme in successive early developing stages lack in literature. The aim of this investigation was to carry out systematic morphologic and stereologic analyses of rat telencephalon in early developmental stages. We analysed semithin (1 microm) serial sections of rat embryonic brain from the 12th (E12) to the 15th (E15) day of gestation. The surface densities (SV) of an external mesenchymal surface, an internal mesenchymal surface and a neuroepithelial (ventricular) surface were examined stereologically and compared. The surface density of the external mesenchymal surface was the biggest at E12 (4,05 mm-1) and the least at E15 (1,87 mm-1)-p<0,0005. The surface density of the internal mesenchymal surface was the biggest at E12 (4,02 mm-1) and the least at E15 (2,69 mm-1)-p<0,0005. The surface density of the internal neuroepithelial surface was the biggest at E12 (3,31 mm-1) and the least at E15 (2,01 mm-1)-p<<0,0005. Our stereological examines give objective numerical proof of significant morphogenetic changes in telencephalon shape described by morphologic analyses. The major advantage of stereological methods is the possibility to carry out the estimation procedures in specified, well-defined brain regions or layers.
Highlights
Development of the human telencephalon begins by enclosing of rostral neuroporus at the cranial end of embryonic neural tube
Unbiased stereological methods have been applied for determining real changes in cell number because of disparity between a density and the total number as a quantitative measure ( )
The major advantage of stereological methods is the possibility to carry out the estimation procedures in specified, well-defined brain regions or layers (, )
Summary
Development of the human telencephalon begins by enclosing of rostral neuroporus at the cranial end of embryonic neural tube ( days of development; crown-rump length , - , mm). It is the beginning of cortex development. Systematic comparative stereological researches of borderline surfaces of mesenchyme and neuroepithelium in early developing stages of rat telencephalon lack in literature. The aim of this investigation was to analyse the earliest stages of the developing rat telencephalon morphologically and quantitatively and to compare sizes of neuroepithelial and mesenchymal surfaces
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