Abstract
Because early embryonic cells are totipotent, the possibility of splitting or separating the blastomeres of early preimplantation embryos to increase the number of embryos that are available for IVF treatment of infertility is being discussed. Because embryo splitting could lead to two or more embryos with the same genome, the term “cloning” has been used to describe this practice. Embryo splitting, however, does not involve any direct manipulation, transfer, or substitution of the entire genome, as occurs in conventional understanding of cloning by nuclear substitution.
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