Abstract
Sickle cell trait occurs in approximately 300 million people worldwide, with the highest prevalence of approximately 30% to 40% in sub-Saharan Africa. If people with sickle cell disease have a chronically activated coagulation system and display hemostatic perturbations, genetic risk factors for venous thromboembolism (VTE) in the black population are poorly understood; in fact common genetic risk factors for VTE in Caucasian people rarely are found among blacks. We report the case of a young Cameroonian man with multiple episodes of thromboembolism, the last of which occurred when he was 36 years old. The major identifiable risk factor for recurrent venous thrombosis was the presence of sickle cell trait.
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