EM4 Recommendations for Handling Uncertainty in Economic Evaluation: A Targeted Review of Pharmacoeconomic Guidelines

Abstract

The appropriate handling of uncertainty is an essential element of economic evaluation of healthcare interventions. Accepted methods include deterministic and probabilistic analyses to characterise parametric uncertainty, and scenario analyses to test uncertainty propagated by methodological and structural assumptions. This targeted review examined which methods for handling uncertainty are recommended in pharmacoeconomic guidelines around the world.