EM.P.1.06 Extracellular matrix metalloproteinase protein inducer (EMMPRIN/CD147) regulates myoblast differentiation through an MMP-mediated control of TGFb activity

Abstract

Skeletal muscle regeneration, mediated through the activation and differentiation of the myogenic stem cells called satellite cells, requires tissue remodeling where MMPs are thought to play an important role. In view of the MMP inducing function of EMMPRIN/CD147, we looked a possible role of EMMPRIN in in vitro myogenesis. As myoblasts, we used both primary cultures of rat satellite cells and the C2.7 cells, a sub clone from C2C12 myoblast cell line. These cells differentiate into myotubes in culture when shifted to low serum medium.