Abstract
Elvax 40P (EVX), an ethylene vinyl-acetate copolymer, has been well characterized as an implant material that causes no inflammatory response and is capable of the sustained, local release of a wide variety of undenatured macromolecules in vivo. To investigate the usefulness of this material in developmental studies we examined the effect of EVX implants containing either deoxycorticosterone acetate (DCA) or testicular hyaluronidase on alveolar differentiation and ductal growth in the mouse mammary gland. DCA implants produced localized alveolar differentiation on ducts, while implants containing Thase caused basal lamina disruption at the duct's growing tip, resulting in epithelial dysplasias. We conclude that EVX implants allow assessment of the primary (nonsystemic) effects of biologically active molecules on developing tissue and should therefore have a variety of interesting experimental uses.
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