Abstract
Abstract Membrane proteins, such as receptors, transporters, and enzymes, play various roles in the survival of organisms. Discovery and development of new bioactive molecules interacting with these proteins are indispensable for understanding the mechanisms of biological events. This account summarizes our efforts on (1) design and synthesis of glutamate transporter blockers to elucidate the mechanism of excitatory neurotransmission process and (2) identification of a novel glycolipid that is essential for membrane protein integration.
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