Abstract
The metabolism of dimethylsulfone was quantified for possible medical applications based on the hypothesis that the agent may be metabolized to yield methionine or its metabolites. The 35S-labeled dimethylsulfone and methionine are orally administrated to rat. Over 80% of the administrated dimethylsulfone is metabolized in the rats tissues, and 59.7–79.1% of it is then excreted into the urine as 35S-containing metabolites; 3.5–10.3% of the same remains incorporated in the tissues. The uptake of radioactivity, though different from the quantity of methionine in percentage at the retained site, is observed in the blood, spleen and hair, and over 80% of the administered [ 35S] dimethylsulfone is excreted the same day. Meanwhile, the distribution of the 35S concentrations of both agents in the rat system suggests that this compound had been metabolized to yield certain sulfur-containing compounds.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
