Abstract
Planar cell polarity (PCP) refers to a periodic arrangement of cells across an axis of a tissue plane through asymmetric localization of five core PCP proteins, one of which is CELSR1, an atypical cadherin. In PCP, CELSR1 localizes to both sides of the cell and selectively recruits other core PCP transmembrane proteins, Frizzled3/6 and Vangl2 to opposing sides within the cell. Cadherins, which are primarily known for cell adhesion, depend on their extracellular cadherin (EC) repeats for function.
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