Abstract
Two leading protein vaccine candidates from Nontypeable Haemophilus Influenzae (NTHi) are outer membrane proteins Omp26 and Protein D. When administered individually, Omp26 and Protein D elicit an antibody response in mice; when combined, the Protein D antibody response is significantly suppressed. Here, we describe a biochemical approach toward elucidating the interactions between Omp26 and Protein D, which we propose contribute to the suppression of Protein D‐specific antibody production. Preliminary data from enzyme‐linked immunosorbent assays and other standard protein detection methods suggest that Protein D binds strongly to Omp26 in vitro and perhaps in vivo in mice.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
