Elucidating molecular mechanisms of the developmental origins hypothesis: p53 phosphorylation, apoptosis, and nephrogenesis

Abstract

epidemiologic studies show that humans born small for gestational age are disposed to developing type 2 diabetes, obesity, hypertension, and cardiovascular disorders (the “metabolic syndrome”) during adulthood ([3][1], [4][2]). The mechanisms by which intrauterine growth restriction (IUGR) leads