ELM 2016--data update and new functionality of the eukaryotic linear motif resource.

Annika Behrendt,Vera Thiel,Brigitte Altenberg,Norman E. Davey,Kim Van Roey ,Sandra Diebel,Toby J. Gibson,Helen Kühn,Sushama Michael,Sabina Merrill,Christina Mäder,Sára Kálmán ,Vladislava Milchevskaya,Sophie L. Dahl ,Lukas Welti,Francesca Diella,Steffen Klein,Holger Dinkel,Angelina Staudt,Manjeet Kumar,Melanie Schneider,Arne C. Knudsen,Victoria Damerell,Bora Uyar

doi:10.1093/nar/gkv1291

Abstract

The Eukaryotic Linear Motif (ELM) resource (http://elm.eu.org) is a manually curated database of short linear motifs (SLiMs). In this update, we present the latest additions to this resource, along with more improvements to the web interface. ELM 2016 contains more than 240 different motif classes with over 2700 experimentally validated instances, manually curated from more than 2400 scientific publications. In addition, more data have been made available as individually searchable pages and are downloadable in various formats.

Highlights

Short Linear motifs (SLiMs) are small protein-interactionmediating modules that have unique properties [1,2]
We present the latest additions to this resource, along with more improvements to the web interface
Eukaryotic Linear Motif (ELM) 2016 contains more than 240 different motif classes with over 2700 experimentally validated instances, manually curated from more than 2400 scientific publications

Summary

Introduction

Short Linear motifs (SLiMs) are small protein-interactionmediating modules that have unique properties [1,2]. ELM 2016 contains more than 240 different motif classes with over 2700 experimentally validated instances, manually curated from more than 2400 scientific publications. The ELM resource provides two main services, a database of short linear motif annotation and a tool that uses this information to explore possible instances of motifs in any given protein sequence.

Results

Conclusion