Abstract
Plasma concentrations of amobarbital were measured in mothers with mild hypertension at term and their newbom infants after administration of a single dose of sodium amobarbital before delivery. Similar drug concentrations were found in cord and matemal plasma immediately after delivery. From the declining amobarbital concentration values, first order elimination kinetics were demonstrated in all cases. The plasma half‐life of amobarbital was 2.5 fimes as long in the newborn as in the mothers. The plasma concentration of the drug's major metabolite, hydroxyamobarbital, increased during 12 to 24 hours after delivery in 2 of the mothers and children and decreased thereafter.
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