Abstract
Microinjection of 40 pmol of the neuroexcitotoxin, kainic acid (KA) in the midbrain periaqueductal grey region (PAG) evoked a significant increase in both defensive and immobile behaviours in rats tested in a social situation. The evoked reactions appeared identical to the rat's natural defensive reaction to attack by a conspecific, although they were evoked by the presence, rather than the attack, of another rat. The long duration and natural appearance of the KA-evoked reactions stand in contrast to the short, ‘explosive’ reactions evoked by injection in the PAG of other excitant amino acids. There was no behavioural evidence of a diminution in the effect of repeated injections of KA in the PAG, nor was there any histological evidence of neurotoxicity.
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