Abstract

 
 CADTH recommends that Trikafta be reimbursed by public drug plans for the treatment of cystic fibrosis (CF) in patients aged 12 years and older who have at least 1 F508del mutation in the CFTR gene if certain conditions are met.
 
 
 Trikafta should be reimbursed for patients who have a percent predicted forced expiratory volume in 1 second (ppFEV1) of 90% or less at the onset of Trikafta treatment.
 
 
 At least 1 of the following must be demonstrated after 6 months of treatment with Trikafta: an increase of at least 5% in ppFEV1, a decrease in the number of pulmonary exacerbations or number of days that antibiotics needed to be taken for pulmonary exacerbations, a decrease in CF-related hospitalizations, no decline in BMI, or an improvement of at least 4 points in the CFQ-R respiratory domain scale. The price of Trikafta must be lowered to be cost-effective and affordable.
 
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
