Abstract
In the case of maturity-onset diabetes mellitus, urinary trehalase and urinary maltase activities were significantly elevated as compared with those of healthy individuals. The urinary trehalase activity in non glucosuric and non proteinuric patients was higher than that in healthy individuals, and the trehalase activity in those diabetics with proteinuria was significantly higher than in those without it (p<0.05). Both urinary trehalase and maltase activities were elevated with increased concentration of urinary β2-microglobulin in this diabetics. Furthermore, urinary trehalase was elevated in disease of short duration (1-4 years), whereas in that of relatively long duration (more than 13 years) the activity was rather low. These results suggest that renal brush borders are damaged in the early stages of the disease and that urinary trehalase is a good indicator of renal tubular damage.
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