Elevation of serum interleukine-6 in hypoalphalipoproteinemia patients A proinflammatory condition

Abstract

HDL molecules have an established role in the regression processes of atherosclerosis as well as a putative role as anti-inflammatory agents. Our study investigated whether hypoalpha-lipoproteinemia, characterized by very low HDL levels, might be associated with increased inflammation markers such as Interleukine-6. In this study, (60) patients with HA were taken, were compared with 40 healthy controls, where the patients group were divided into two groups, the first group: HA without CHD group: included thirty (30) patients with hypoalphalipoproteinemia and without coronary heart disease aged (31-60 years). The second group: HA with CHD: included thirty (30) patients with hypoalpha-lipoproteinemia and coronary heart disease, documented by angiography aged (31-60 years). Control group: included forty (40) supposed healthy subjects aged (31-60 years). The results showed a significant increase in the levels of (IL-6) in all groups of patients compared to control groups (P<0.05). In the patient group, IL-6 values were significantly higher in subjects with angiographically documented coronary atherosclerotic disease than in those without. Moreover, IL-6 concentrations were inversely correlated with HDL cholesterol. Also our study shows that negative correlation between HDL and (Total cholesterol, TG, LDL, VLDL, Atherogenic index and HS-CRP).