Abstract
Summary Following an erythropoietic dose of cobalt in rats, elevations in renal guanosine 3′,5′-monophosphate (cyclic GMP) concentrations occurred within 10 minutes reaching peak levels within 40 minutes of injection. Subsequent to the cyclic CMP changes, activities of lysosomal enzymes in plasma (β-glucuronidase, acid phosphatase) increased markedly, with maximal elevations of both enzyme activities occurring 2 hours after cobalt treatment. Bilateral nephrectomy abolishes the elevations in plasma lysosomal enzyme activity following cobalt treatment, suggesting that the kidney is the source of these enzymes. It is proposed that a cyclic GMP-mediated release of lysosomal enzymes from the kidney may be an early effect of cobalt leading to the generation of renal erythropoietin.
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