Abstract
ABSTRACT We have investigated the capacity of various preparations of RNA and DNA to affect the level of 3β-hydroxysteroid dehydrogenase in the adrenals and ovaries of normal rats, and the depressed level of the dehydrogenase in rats treated with an analog of a C-19 substrate of this enzyme. The preparations included nucleic acids from beef adrenals, and from adrenals, livers and spleens of non-inhibited rats, and adrenals from rats inhibited with the analog. Control preparations consisted of extracts treated with RNase and DNase, and polyuridylic acid. Injection of any nucleic acid preparation produced a significant increase both of the wet weight and of the level of activity of the dehydrogenase (activity/mg tissue protein) in each gland of normal and inhibited rats. The increase in gland weight was a reflection of a rise in total gland protein. Treatment of the extracts with RNase and DNase prior to administration to the analog-treated animals reduced these effects the levels occurring in analog-treate...
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