Elevation of Lactate Dehydrogenase & its Isoenzyme Pattern in Pregnancy induced Hypertension: Etiopathogenesis and Consequences

Abstract

Lactate dehydrogenase (LDH) is an intra cellular cytosolic enzyme, which play an important role in anaerobic Glycolysis. It is a tetramer having four subunits which may be all H type or all M type or it may be a mix of both these subunits. Preeclampsia is defined as a pregnancy-specific multi-systemic syndrome of widespread endothelial malfunction and vasospasm developing after 20 weeks of gestation. Analysis of Isoenzyme pattern of LDH is more important than Total LDH value, anaerobic form LDH is seen to be predominantly found in case of pre-eclampsia.