Abstract
Subcutaneous injection of indomethacin to pentobarbital-anesthetized rats markedly reduced gastric blood flow measured by hydrogen clearance method in the antrum and fundus of the stomach. Intraperitoneal injection of Pro-Gly-Pro 10 min after the administration of indomethacin normalized gastric blood flow. These data indicate that the elevation of reduced regional blood flow in the stomach is one of possible mechanisms of antiulcer effects of Pro-Gly-Pro.
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