Abstract
BackgroundFatty acid-binding protein 4 (FABP4) is expressed in both adipocytes and macrophages. Recent studies have shown secretion of FABP4 from adipocytes and association of elevated serum FABP4 level with obesity, insulin resistance, hypertension, and atherosclerosis. However, little is known about role of FABP4 in cardiac function.MethodsFrom the database of the Tanno-Sobetsu Study, data for 190 subjects (male/female: 82/108) who were not treated with any medication and underwent echocardiography in 2011 or 2012 were retrieved for analyses of relationships between serum FABP4 concentration, metabolic markers and parameters of echocardiography.ResultsSerum FABP4 level was positively correlated with age, body mass index (BMI), blood pressure (BP), LDL cholesterol, HOMA-R and mean left ventricular (LV) wall thickness (LVWT, males: r = 0.315, females: r = 0.401, p < 0.01) and was negatively correlated with HDL cholesterol, estimated glomerular filtration rate (eGFR) and peak myocardial velocity during early diastole (e’; males: r = −0.434, females: r = −0.353, p < 0.01), an index of LV diastolic function. However, no significant correlation was found between FABP4 level and LV end-diastolic dimension, LV ejection fraction or LV mass index. There were significant correlations of e’ with age, BMI, BP, eGFR, brain natriuretic peptide (BNP), FABP4, metabolic markers and LVWT. Multivariate regression analysis adjusted by HOMA-R, BMI, eGFR, BNP or LVWT in addition to age, gender and BP revealed that serum FABP4 concentration was independently correlated with e’.ConclusionsElevation of circulating FABP4 may contribute to LV diastolic dysfunction in a general population.
Highlights
Fatty acid-binding protein 4 (FABP4) is expressed in both adipocytes and macrophages
Male subjects were significantly older than the female subjects and they had significantly larger body mass index (BMI) and waist circumference and had higher levels of systolic and diastolic blood pressures, triglycerides, glucose, Hemoglobin A1c (HbA1c), insulin, HOMA-R and Cr and lower levels of total cholesterol, high-density lipoprotein (HDL) cholesterol, Low-density lipoprotein (LDL) cholesterol and FABP4 than did the females
It is notable that the correlation of FABP4 level with e’ was independent of age, BMI, HOMA-R and left ventricular (LV) wall thickness (Table 4). These results suggest that serum FABP4 is a novel marker of LV diastolic dysfunction and potentially a predictor of heart failure with preserved ejection fraction (HFpEF)
Summary
Fatty acid-binding protein 4 (FABP4) is expressed in both adipocytes and macrophages. Recent studies have shown secretion of FABP4 from adipocytes and association of elevated serum FABP4 level with obesity, insulin resistance, hypertension, and atherosclerosis. Fatty acid-binding proteins (FABPs) are a group of intracellular lipid chaperones that coordinate lipid responses in cells [1,2]. Among FABPs, fatty acid-binding protein 4 (FABP4), known as Adipose tissue is known to secrete a variety of bioactive molecules called adipokines, such as tumor necrosis factor-α (TNFα), leptin and adiponectin, which are implicated in a wide range of biological phenomena. Elevated serum concentration of FABP4 has been shown to be associated with obesity, insulin resistance, hypertension and atherosclerosis [8,9,10,11,12]
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