Elevated ZNF703 Protein Expression Is an Independent Unfavorable Prognostic Factor for Survival of the Patients with Head and Neck Squamous Cell Carcinoma.

Hang Yang,Xin An,Zhong-Yu Yuan,Yong-An Sun,Wen-Qi Jiang,Rou-Jun Peng,Ye Cao,Ying-Chun Zhang,Li-Ren Li,Shu-Sen Wang,Ming Song,Tan-Huan Chen,Yan-Xia Shi,Jing Wei

doi:10.1155/2015/640263

Abstract

Aim. Data from The Cancer Genome Atlas (TCGA) show that the ZNF703 gene amplifies and overexpresses in head and neck squamous cell carcinomas (HNSCC). However, the clinical relevance of this observation in HNSCC is unclear. The purpose of this study was to clarify the expression of ZNF703 protein and its prognostic effect on HNSCC. Methods. Two hundred ten HNSCC patients from Sun Yat-Sen University Cancer Center with complete survival follow-up were included in this study. Tumor samples from primary sites were collected. The expression of the ZNF703 protein was tested by immunohistochemistry (IHC). Results. The high expression of ZNF703 in HNSCC tumor tissues was significantly higher than that of the matched noncancerous tissues (48.6% versus 11.6%, P < 0.001). ZNF703 overexpression was correlated with tumor position (laryngeal carcinoma) and recurrence (all P < 0.05). Multivariate analysis revealed that ZNF703 protein overexpression was an independent prognostic factor (P = 0.022, hazard ratio = 1.635, 95% CI 1.073–2.493) in HNSCC patients. Conclusion. ZNF703 overexpression is associated with adverse prognosis in HNSCC, which might be a novel biomarker of HNSCC.

Highlights

Head and Neck Squamous Cell Carcinoma (HNSCC) is the sixth most common malignancy in the world, with approximately 600,000 newly diagnosed cases per year [1, 2]
HNSCC is a group of fairly heterogeneous tumors that can occur from the base of the cranium to the clavicles
The 5-year overall survival time (OS) rate was 58.9% and 68.2% in the high and low expression groups, respectively. All these results indicated that ZNF703 may play a role in the tumorigenesis and metastasis of HNSCC and act as an oncogene

Summary

Introduction

Head and Neck Squamous Cell Carcinoma (HNSCC) is the sixth most common malignancy in the world, with approximately 600,000 newly diagnosed cases per year [1, 2]. HNSCC is a group of fairly heterogeneous tumors that can occur from the base of the cranium to the clavicles. On the basis of anatomic sites, HNSCC can be divided into various types; the paranasal sinuses, nasal cavities, nasopharynx, orbits, oral cavity, oropharynx, hypopharynx, and larynx make up 90% of HNSCC and the 5-year survival rate of all HNSCC is approximately 50% [3]. Patients diagnosed at an early stage can have a superior quality of life and life expectancy with surgery alone [3]. For patients in stage IV, the long-term survival of HNSCC

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