Elevated urinary phenol levels in beagle dogs treated with salol.

Abstract

Dogs administered 500 or 250 mg of salol/kg/day showed transient toxicity of a reversible nature. Doses of 125 mg salol/kg/day caused no discernible ill effects in spite of urinary phenol levels elevated as high as 6144 ppm. It appears as if exposure to a compound other than benzene can cause an elevation of urinary phenol.