ELEVATED TRIGLYCERIDE TO HIGH-DENSITY LIPOPROTEIN CHOLESTEROL RATIO INCREASED RISK OF HYPERURICEMIA IN CHINESE ADULTS: A 4-YEAR COHORT STUDY

Abstract

Objective: Previous studies showed that high serum uric acid (SUA) levels associated with elevated triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio. However, evidence is lacking regarding whether TG/HDL-C is an independent risk factor. Our aim was to investigate the association between TG/HDL-C and the risk of hyperuricemia in Chinese population after adjusting for relevant risk factors. Design and method: This retrospective cohort study included 15,198 participants with an average age of 43 years who did not have hyperuricemia at baseline. The association between TG / HDL-C and the risk of hyperuricemia in the total sample was examined by multiple logistic regression analysis. To completely rule out the impact of metabolic syndrome on the relationship between TG/HDL-C and hyperuricemia, we reevaluate the relationship between TG/HDL-C and hyperuricemia in participants without metabolic syndrome (N = 12,813). Results: During a 4-year follow-up, 2,365 (15.6%) participants developed hyperuricemia. With the increase of the TG/HDL-C quartile, the cumulative incidence of hyperuricemia increased significantly (5.9,10.8, 18.4, and 27.5%, respectively). After multivariate adjustment, the odds ratio (OR) for hyperuricemia in the highest compared with the lowest quartile of TG/HDL-C was 1.80 (95% confidence interval [CI] 1.49, 2.18), and each SD increment of TG/HDL-C ratio caused a 10% additional risk for hyperuricemia. The cumulative incidence of hyperuricemia was also significantly elevated with increasing TG/HDL-C quartiles (5.6, 9.4, 15.5, and 24.0%, respectively) in participants without metabolic syndrome. The OR for hyperuricemia in the highest compared with the lowest quartile of TG/HDL-C was 1.70 (95% CI 1.38–2.10), and each SD increment of TG/HDL-C ratio caused a 18% additional risk for hyperuricemia in people without metabolic syndrome after adjusting for all confounders. Conclusions: Elevated TG/HDL-C ratio increased future risk of hyperuricemia in Chinese population. This association suggested the potential of TG/HDL-C ratio to serve as an independent risk indicator in the prevention of hyperuricemia.