Abstract
In this study, we sought to determine whether sperm DNA fragmentation (DFI%) and high DNA stainability (HDS%) evaluated by sperm chromatin structure assay (SCSA) predict recurrent implantation failure (RIF) or pregnancy rate. A retrospective study was performed of consecutive cycles of ICSI treatment from 2009 to 2018. A total of 386 couples that underwent 1,216 frozen embryo transfer (FET) cycles were analysed. Mean female and male age was 34±3.6years and 37.3±6.6years, respectively, and a median total motile sperm count (TMSC) was 43.5 [9.9-105.5] million. Overall median DFI% and HDS% was 12 [7.1-18.9] and 9.6 [6.5-14.4] respectively. On multivariable analysis, DFI% and HDS% were not associated with RIF (DFI%: OR=1.01, 95% CI: 0.98-1.04, p=.414; HDS%: OR=0.97, 95% CI: 0.94-1.01, p=.107) or IVF success, defined as clinical pregnancy (DFI%: OR=1.00, 95% CI: 0.99-1.01, p=.641; HDS%: OR=1.01, 95% CI: 0.99-1.02, p=.565). We found that neither DFI% or HDS%, as assessed by SCSA, were predictive of RIF or pregnancy rate. This finding suggests that sperm DNA fragmentation does not predict RIF or pregnancy rate.
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