Abstract
BackgroundThe metabolic effect of fructose in sugar-sweetened beverages (SSB) has been linked to de novo lipogenesis and uric acid (UA) production.ObjectivesThis study investigated the biological effects of SSB consumption on serum lipid profiles and retinol-binding protein 4 (RBP4) among Taiwanese adolescents.MethodsWe evaluated the anthropometric parameters and biochemical outcomes of 200 representative adolescents (98 boys and 102 girls) who were randomly selected from a large-scale cross-sectional study. Data were analyzed using multiple regression models adjusted for covariates.ResultsIncreased SSB consumption was associated with increased waist and hip circumferences, body mass index (BMI) values and serum UA, triglyceride (TG) and RBP4 levels. Adolescents who consumed >500 ml/day of beverages half-to-heavily sweetened with high-fructose corn syrup (HFCS) exhibited TG and RBP4 levels 22.7 mg/dl and 13.92 ng/ml higher than non-drinkers, respectively. HFCS drinkers with hyperuricemia had higher TG levels than HFCS drinkers with normal UA levels (98.6 vs. 81.6 mg/dl). The intake of HFCS-rich SSBs and high value of BMI (≥24) interactively reinforced RBP4 levels among overweight/obese adolescents. Circulating RBP4 levels were significantly correlated with weight-related outcomes and TG and UA concentration among HFCS drinkers (r = 0.253 to 0.404), but not among non-drinkers.ConclusionsHigh-quantity HFCS-rich beverage consumption is associated with higher TG and RBP4 levels. Hyperuricemia is likely to intensify the influence of HFCS-rich SSB intake on elevated TG levels, and in overweight and obese adolescents, high BMI may modify the action of fructose on higher circulating levels of RBP4.
Highlights
Retinol-binding protein 4 (RBP4)—the single specific transporter of vitamin A in blood—is a lipocalin-family protein secreted by mature adipocytes and activated macrophages in adipose tissue [1,2]
High-quantity high-fructose corn syrup (HFCS)-rich beverage consumption is associated with higher TG and RBP4 levels
Hyperuricemia is likely to intensify the influence of HFCS-rich sugar-sweetened beverages (SSB) intake on elevated TG levels, and in overweight and obese adolescents, high body mass index (BMI) may modify the action of fructose on higher circulating levels of RBP4
Summary
Retinol-binding protein 4 (RBP4)—the single specific transporter of vitamin A in blood—is a lipocalin-family protein secreted by mature adipocytes and activated macrophages in adipose tissue [1,2]. Biochemical investigations of lean, obese and diabetic participants have demonstrated that the concentration of serum. Animal studies have shown that serum RBP4 levels are elevated in the adipose tissue of mice with genetic knockout of adipose-specific GLUT4 [5]. In participants with various clinical presentations, serum RBP4 has been positively correlated with insulin resistance and is an important adipokine associated with type 2 diabetes and cardiovascular complications [3,6,7,8,9]. Recent studies have suggested that RBP4 may produce a molecular connection between obesity and insulin resistance [10]. The metabolic effect of fructose in sugar-sweetened beverages (SSB) has been linked to de novo lipogenesis and uric acid (UA) production
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