Abstract
BackgroundOsteoprotegerin (OPG) is a potential biomarker for severity and complications of cardiovascular diseases. Peripheral arterial disease (PAD) is associated with an increased risk of death in kidney transplantation (KT) patients. This prospective cross-sectional study evaluated the relationship between serum OPG and PAD in KT patients.MethodsSeventy-four KT patients were enrolled for this PAD study. Fasting blood samples were obtained to measure serum OPG levels by using enzyme-linked immunosorbent assay kits. The ankle-brachial index (ABI) of less than 0.9 was applied for PAD diagnosis.ResultsThirteen patients (17.6%) were diagnosed with PAD. Diabetes (P = 0.025), smoking (P = 0.010), and increased OPG levels (P = 0.001) were significantly more frequent in the PAD group. Multivariate logistic regression analysis showed that serum OPG (odds ratio [OR], 1.336; 95% CI [1.108–1.611]; P = 0.002) and diabetes (OR, 7.120; 95% CI [1.080–46.940]; P = 0.041) were independent predictors of PAD in KT patients. The area under the receiver operating characteristic (ROC) curve determined that the probability of a serum OPG level of 7.117 pg/L in predicting PAD in KT patients was 0.799 (95% CI [0.690–0.884]; P < 0.001).DiscussionExploration of reliable biomarkers for early identification of vascular risk is crucial for KT patients. Elevated serum OPG levels may predict PAD in KT patients with cutoff value of 7.117 pg/L.
Highlights
Peripheral arterial disease (PAD) is a common manifestation of atherosclerotic vascular disease that is associated with significant morbidity and mortality (Criqui & Aboyans, 2015)
Establishing PAD diagnosis in clinical practice can be achieved by utilizing ankle-brachial index (ABI), which is a marker of atherosclerosis (Cooke & Wilson, 2010)
The present study showed that serum OPG, diabetes, and smoking were associated with PAD in kidney transplantation (KT) patients
Summary
Peripheral arterial disease (PAD) is a common manifestation of atherosclerotic vascular disease that is associated with significant morbidity and mortality (Criqui & Aboyans, 2015). Several studies showed that a decrease in ABI is associated with increased risks of stroke, cardiovascular disease, and all-cause mortality (Doobay & Anand, 2005). In the Assessment of LEscol in the Renal Transplantation (ALERT) study, elevated serum OPG levels were independently associated with the deterioration of renal function, cardiovascular events, and all-cause mortality in KT patients (Svensson et al, 2012). The purpose of the current study was to determine the relationship between serum OPG level and PAD, as determined by ABI, in KT patients. Peripheral arterial disease (PAD) is associated with an increased risk of death in kidney transplantation (KT) patients. This prospective cross-sectional study evaluated the relationship between serum OPG and PAD in KT patients. Elevated serum OPG levels may predict PAD in KT patients with cutoff value of 7.117 pg/L
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