Elevated Serum Myeloid-Related Protein (MRP) 8/14 in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease

Abstract

The current study aims to evaluate the expression and clinical significance of myeloid-related protein (MRP) 8/14 in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). The levels of MRP8/14, TNF-α, and IL-1β in the serum of the patients with AECOPD were determined using ELISA assay. The correlation between the expression of MRP8/14 and TNF-α, IL-1β, forced expiratory volume in one second FEV1 % pred in AECOPD patients was analyzed using Pearson's correlation assay. Receiver operating characteristic (ROC) analysis was performed to evaluate the diagnostic value of serum MRP8/14 in AECOPD patients. The levels of MRP8/14, TNF-α, and IL-1β in the serum of the patients with AECOPD were significantly higher than those in the control group. Furthermore, the expression of MRP8/14 was positively correlated with TNF-α, IL-1β, and negatively correlated with FEV1 % pred. In addition, the level of serum MRP8/14 in GOLD 3-4 patients was higher than that in GOLD 1 - 2 patients. Meanwhile, the level of serum MRP8/14 in AECOPD patients with mMRC 3 - 4 was higher than that in patients with mMRC 0 - 2. ROC analysis showed that serum MRP8/14 could differentiate AECOPD patients from healthy controls. Altogether, elevated serum MRP8/14 level plays a key role in chronic airway inflammation and may be a useful marker in the diagnosis of AECOPD patients.