Elevated serum macrophage migration inhibitory factor levels correlate with benign paroxysmal positional vertigo and recurrence events.

Hong-Bin Cai,Zi-Chao Li,Lei Duan,Zhao-Ming Ge,Chong-Chong Zhao,Ting Tian

doi:10.1042/bsr20191831

Hong-Bin Cai, Zi-Chao Li + Show 4 more

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https://doi.org/10.1042/bsr20191831

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Journal: Bioscience reports	Publication Date: Aug 23, 2019
Citations: 5	License type: CC BY 4.0

Affiliation: Lanzhou University

Abstract

Objective: We aimed to assess the possible relations between serum levels of macrophage migration inhibitory factor (MIF), a central cytokine of the innate immunity and inflammatory response, and benign paroxysmal positional vertigo (BPPV) risk and BPPV recurrence events.Methods: In the present study, 154 patients with BPPV, and 100 age-and sex-matched control subjects were enrolled in the study. All the patients and controls underwent a complete audio‐vestibular test battery including the Dix–Hallpike maneuver and supine roll test. In the BPPV group, measurements of MIF levels were repeated 1 month after the vertigo attack. The patients were also divided into the recurrence group and the nonrecurrence group in the 1-year follow-up.Results: The serum levels of MIF in patients with BPPV were higher than in those controls (13.9[interquartile range {IQR}, 8.9–18.4] ng/ml vs. 9.8[7.8–11.8]; P<0.001). As a continuous variable, MIF was associated with increased risk of BPPV (odds ratio [OR] 1.21, 95% confidence interval [CI]: 1.11–1.39; P=0.004) in multiple regression analyses. Recurrent attacks of BPPV were reported in 35 patients, and those patients had higher levels of MIF than those patients were not recurrence (18.0[IQR, 13.6–22.2] ng/ml vs. 12.6[9.3–16.8] ng/ml). In multivariate models comparing the second (Q2), third (Q3) and fourth(Q4) quartiles against the first (Q1) quartile of MIF, levels of MIF in Q4 were associated with recurrent BPPV, and the odds were increased by approximately 305% (OR = 4.05; 95%CI: 1.65–15.44; P=0.009).Conclusions: Elevated MIF is positively correlated with BPPV risk and BPPV recurrence events, requiring further efforts to clarify the exact mechanism.

Highlights

Of all the inner ear disorders that can cause dizziness or vertigo, benign paroxysmal positional vertigo (BPPV) is by far the most common [1]
There was no significant association between the parameters of systolic blood pressure (SBP), diastolic blood pressure (DBP), smoking, drinking and regular exercise habit in patients with BPPV compared with controls (P>0.05)
In multivariate models comparing the second (Q2), third (Q3) and fourth(Q4) quartiles against the first (Q1) quartile of migration inhibitory factor (MIF), levels of MIF in Q4 were associated with recurrent BPPV, and the odds were increased by approximately 305% (OR = 4.05; 95%confidence interval (CI): 1.65–15.44; P=0.009)

Summary

Introduction

Of all the inner ear disorders that can cause dizziness or vertigo, benign paroxysmal positional vertigo (BPPV) is by far the most common [1]. BPPV is a disease of altered endolymph and cupular mechanics secondary to dislodged otoconia [2]. BPPV patients have episodic vertigo provoked by head movements, and they show classical horizontal, vertical or torsional nystagmus with the characteristics of latency, crescendo and decrescendo pattern, fatigability and reversibility [3]. BPPV can cause severe impact on the quality of life due to reduced daily activities, falls and depression [4]. BPPV includes two types: posterior semicircular canal (PSC) and horizontal semicircular canal (HSC). The PSC is accounting for up to 90%, whereas the HSC cases only occur in 5–15% of patients [5]

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