Abstract
Elevated serum HER-2 predicts poor prognosis in breast cancer and is correlated to ADAM10 expression
Highlights
Breast cancer is the most frequent type of cancer and the most common cause of cancer‐related mortality among women worldwide.[1]
A human epidermal growth factor receptor‐2 (HER‐2)‐positive result requires the demonstration of HER‐2 protein overexpression (3+ staining by IHC) or HER‐2 gene amplification by fluorescent in situ hybridization (FISH).[8,9]
In our opinions, elevated a disintegrin and metalloproteinase 10 (ADAM10) protein expression may be a negative feedback to inhibition of ADAM10 function, and further indicated that HER‐2 extracellular domain (ECD) shedding was exactly associated with alpha‐secretase activity of ADAM10
Summary
Breast cancer is the most frequent type of cancer and the most common cause of cancer‐related mortality among women worldwide.[1]. The treatment with trastuzumab is expensive and tissue HER‐2 negative patients do not benefit from it, so it is important to determine tumor HER‐2 status.[7]. A HER‐2‐positive result requires the demonstration of HER‐2 protein overexpression (3+ staining by IHC) or HER‐2 gene amplification by FISH.[8,9] The accurate identification of HER‐2 status is critical to the appropriate management of breast cancer patients. The currently available tissue diagnostic methods for HER‐2 have their own limitations, such as discordance between IHC and FISH diagnosis,[10] inter‐laboratory variability.[11] In this instance, serum HER‐2 evaluation was generated as a potentially additional diagnosis for HER‐2 expression. We will explore correlation between serum HER‐2 ECD shedding and HER‐2 expression status in breast tumor tissues. We will uncover the potential clinical significance of serum HER‐2 ECD detection
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