Elevated serum βhCG and dyslipidemia in second trimester as predictors of subsequent Pregnancy Induced Hypertension.

Mp Mallick,R Medhi,S Bisai,S Ray

doi:10.3329/bmrcb.v40i3.25230

Abstract

To test the hypothesis that pregnant women with high serum βhCG level and serum dyslipidemia in second trimester are more prone to develop subsequent Pregnancy Induced Hypertension (PIH). One hundred pregnant women with singleton pregnancy between 14 and 20 weeks of gestation attending antenatal outpatient department (OPD) of SMCH were studied. Serum βhCG was estimated by two-site chemiluminescent-immunometric method. Serum lipid profile was evaluated by enzymatic colorimetric test with Lipid Clearing Factor (LCF). Eighteen cases developed PIH while eighty two cases remained normotensive. The serum βhCG level was significantly high (p (see symbol) 0.001) in those women developing PIH. Serum concentration of total cholesterol in women who subsequently developed PIH was significantly higher than that of normotensive group (p (see symbol) 0.05). Mean TG value in PIH group was higher than the normotensive group. Level of LDL in PIH group was also significant (p (see symbol) 0.05). Present study showed that elevated serum βhCG and Dyslipidemia in second trimester can be considered as predictors of subsequent PIH / Pre-eclampsia. However, there is need of large community based prospective study to validate the result.

Highlights

Hypertensive disorder of pregnancy (HDP) is one of the commonest complications of pregnancy with adverse feto-maternal consequences
Comparison of mean ± SD for blood pressure at the time of enrolment (14-20 weeks) between the Pregnancy Induced Hypertension (PIH) and normotensive group does not differ significantly except a higher diastolic blood pressure in PIH/Pre-eclampsia group at this stage. Both diastolic and systolic blood pressure for PIH at the time of delivery is significantly higher than the level of the normotensive group (Table-I)
In this study prevalence rate of PIH/Pre-eclampsia increases as the level of maternal serum β increases, 95% prevalence rate in those women having serum βhCG level 40,000 mlU/ml and above

Summary

Introduction

Hypertensive disorder of pregnancy (HDP) is one of the commonest complications of pregnancy with adverse feto-maternal consequences. Half of this hypertension related death is preventable.[5]

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Conclusion