Elevated serum free thyroxine by thyroxine analog radioimmunoassays in euthyroid patients with familial dysalbuminemic hyperthyroxinemia.

Abstract

Brief Reports1 December 1982Elevated Serum Free Thyroxine by Thyroxine Analog Radioimmunoassays in Euthyroid Patients with Familial Dysalbuminemic HyperthyroxinemiaRAJATA RAJATANAVIN, M.D., LAWRENCE FOURNIER, A.A., DIANE DeCOSIMO, M.D., CYNTHIA ABREAU, B.S., LEWIS E. BRAVERMAN, M.D.RAJATA RAJATANAVIN, M.D.Search for more papers by this author, LAWRENCE FOURNIER, A.A.Search for more papers by this author, DIANE DeCOSIMO, M.D.Search for more papers by this author, CYNTHIA ABREAU, B.S.Search for more papers by this author, LEWIS E. BRAVERMAN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-97-6-865 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptVarious radioimmunoassay kits have been developed for measuring the serum free thyroxine (T4) concentration. Values for free T4 obtained with these kits correlate well with values obtained by the more cumbersome and time-consuming method of equilibrium dialysis in patients with thyroid dysfunction and abnormalities in the serum thyroxine-binding globulin concentration (1, 2). However, when some of these kits are used to assess serum free T4 in euthyroid patients with nonthyroidal illnesses, the values may be lower than those obtained with equilibrium dialysis (2-5). These discrepancies may limit the clinical usefulness of these methods in ill, euthyroid patients.Familial dysalbuminemic hyperthyroxinemia...