Elevated serum cartilage oligomeric matrix protein and the metalloproteinase‐ADAMTS7 levels are associated with vascular calcification in maintenance hemodialysis patients

Abstract

Vascular calcification is common in maintenance hemodialysis (HD) patients. Recent studies showed that cartilage oligomeric matrix protein (COMP) could protect blood vessels fromcalcification, but the role of ADAMTS7 was opposite. We aimed to investigate the relationship between serum COMP, ADAMTS7 levels and vascular calcification scores in HD patients. Serum COMP and ADAMTS7 levels were tested by ELISA and we compared calcification scores between high and low COMP groups, also between high and low ADAMTS7 groups. We also investigated the differences of serum COMP and ADAMTS7 levels between mild and severe vascular calcification groups. The relationship between serum COMP and ADAMTS7 levels was analyzed in the end. Serum COMP and ADAMTS7 levels were both higher in HD patients than in control (29.63 vs 14.23ng/mL, P=.002, 11.12 vs 2.40ng/mL, P=.005). Serum COMP levels in severe vascular calcification (VC) group were higher than in mild VC (43.13±28.77 vs 26.75±18.22ng/mL, P=.010). Serum ADAMTS7 levels were positively correlated with radial and digital arteries (small arteries) calcification scores (r=.249, P=.033). And serum COMP and ADAMTS7 levels were positively correlated (r=.348, P=.026). Serum COMP and ADAMTS7 levels were probably associated with vascular calcification scores in HD respectively.