Abstract
The CA-125 antigen is expressed on a glyco protein produced by the cells derived from the coelomic epithelium and can be detected in the pleura, pericardium, peritoneum and the Mill lerian duct derivatives.' Serum CA-125 concen tration is elevated in the vast majority of patients with ovarian cancer and has proved to be a very useful tumour marker in these patients. How ever, serum CA-125 concentrations may also be elevated in a large number of other malignant diseases such as colorectal, breast, lung and pancreatic cancer. In addition, elevated serum CA-125 concentrations may be found in other conditions, including pleural effusions and ascites irrespective of the cause. In recent years elevated serum CA-125 has also been demonstrated in patients with non-Hodgkin's Iymphoma.v? In the cases reported, no immuno reactivity for CA-125 on the lymphoma cells could be demonstrated and it was proposed that the elevated CA-125 concentration was a reactive phenomenon.t-' However, it was shown recently that lymphoma cells might secrete CA-125 under specific conditions.!" We report a case which provides further evidence that high serum CA-125 concentrations in patients with malignant lymphoma may be derived from the tumour cells.
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