Abstract
Abstract Resistin, a protein produced by immune cells in human, causes insulin resistance and impairs the reactive oxygen species (ROS) production in granulocytes. Recent studies suggested that IL-1β production in pulmonary tuberculosis (TB) correlates with inflammasome activation which may be regulated by ROS. We first investigated the serum levels of resistin in pulmonary TB patients with different clinical severity. We found that serum resistin levels were significantly higher in severe TB cases and diabetes-only (DM) group when compared with mild TB cases and healthy controls. Moreover, elevation of serum resistin correlated with impairment of ROS production of granulocytes in DMTB cases. In human macrophages, we further demonstrated that resistin inhibits ROS production and ROS regulated the mycobacterium-mediated inflammasome activation. Finally, using macrophages derived from WT and Ncf1-/- mice, we verified that ROS regulate the mycobacterium mediated inflammasome activation. We concluded that resistin, which suppresses the mycobacterium-mediated inflammasome activation through inhibition of ROS production, is a useful biomarker in severe pulmonary tuberculosis.
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