Abstract
The idiopathic hypereosinophilic syndrome (IHES) is characterized by persistent eosinophilia of more than 1500/mm 3 and a variety of resultant organ damage, and these parameters allow classification of patients into four clinical categories. This syndrome is extremely rare in children. The most common immunologic abnormality in patients with IHES is an elevated serum immunoglobulin level (IgG, IgM, and/or IgE). However, no consistent abnormality has been detected in T-cell function. 1 We describe a child with IHES whose T cells produced elevated levels of interleukin (IL)-4 and IL-5.
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