Elevated Plasma Adiponectin and Leptin Levels in Sisters With Genetically Defective Insulin Receptors

Abstract

Circulating levels of adiponectin have been shown to inversely correlate with insulin sensitivity. Interestingly, elevated adiponectin levels have been observed following treatment with thiazolidinediones. It has recently been reported (1) that paradoxical hyperadiponectinemia is observed in patients with mutations, leading to a loss of insulin receptor function. Here, we evaluated circulating levels of adiponectin and leptin following treatment with pioglitazone in two sisters referred for evaluation of hirsutism who were found to have insulin resistance secondary to an insulin receptor mutation. A 15-year-old Japanese female patient, the younger of the two sisters, has been amenorrheic since menarche at age 12 years. …