Abstract
It has been established that the tumor microenvironment (TME) has a crucial role in enabling tumors to evade from host immune responses. Previous studies demonstrated that tumor cells are not only able to reshape immune milieu at the tumor site, but also exert systemic effects, which has been demonstrated to be important for metastasis. At present, how the peripheral immune environment change in the tumor-bearing host is unclear. The present study identified a number of changes in the proportions of lymphocyte subpopulations and the levels of cytokines in patients with NSCLC, which may provide a preliminary profile of the immune environment in the peripheral blood of patients harboring a tumor. These findings expand on the present knowledge on how tumors can alter the immune system to benefit its growth and metastasis, which may provide a potential novel strategy for immunotherapy.
Highlights
Malignant tumor is able to elicit host immune response [1,2,3,4]
The results indicated that the percentage of lymphocytes in the non‐small cell lung cancer (NSCLC) group was significantly lower compared with the control group (P=0.008; Fig. 2)
The proportion of DN T cells (CD3+CD4‐CD8‐) among lymphocytes in the NSCLC group was significantly lower compared with the control group (P=0.001; Fig. 4 and Table II)
Summary
Malignant tumor is able to elicit host immune response [1,2,3,4]. According to the cancer immunoediting theory, subpopulations of genetically heterogeneous neoplastic cells evolve to escape immune surveillance and thrive [5]. Numerous experimental and clinical studies have demonstrated that tumor cells surviving from The critical role of TME in altering the biological behaviors of tumors have been established, and it is proposed that genetic alterations in neoplastic cells as well as the host immune system affect tumorigenesis and progression [16]
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