Abstract
Altered mean platelet volume (MPV) is implicated in several malignancies. However, the clinicopathological significance and prognostic value of MPV in colorectal cancer (CRC) is still elusive. The purpose of this study was to elucidate the predictive significance of MPV in CRC. The retrospective study recruited 509 consecutive CRC patients between January 2009 and December 2009. The relationships between MPV and clinicopathological characteristics were analyzed. Kaplan-Meier method and Cox regression were used to evaluate the prognostic impact of MPV. Of the 509 CRC patients, high MPV levels were detected in 150 (29.5%) patients. Elevated MPV was associated with tumor differentiation (p < 0.001). Patients with increased MPV had poor overall survival compared with those with normal level (60.0% vs. 83.6%, log-rank test, p = 0.035). Cox regression analysis showed that MPV was an independent prognostic factor in CRC (HR = 1.452, 95% CI = 1.118–1.884, p = 0.005). In conclusion, MPV is easily available in routine blood test. Elevated MPV might act as a marker of prognosis and therapeutic target for CRC.
Highlights
Colorectal cancer (CRC) is the third most commonly diagnosed cancer in males and the second in females
A ROC curve for Overall survival (OS) prediction was plotted to verify the optimal cut-off value for Mean platelet volume (MPV), which was 8.6 (Fig. 1). It demonstrated that MPV predicts cancer prognosis with a sensitivity of 33.8% and a specificity of 76.4% (AUC = 0.551, 95% confidence interval (CI): 0.507–0.551, p = 0.011)
This study found that MPV is correlated with patient’s survival and is an independent risk factor for prognosis
Summary
Colorectal cancer (CRC) is the third most commonly diagnosed cancer in males and the second in females. There are many established therapeutic strategies including surgery, chemotherapy and radiotherapy, the high rate of relapse and distant metastasis still threaten a large percentage of patients. Increased platelets are correlated with a decrease in overall survival and poorer prognosis in various types of cancer, including pancreatic cancer, gastric cancer, colorectal cancer, endometrial cancer, and ovarian cancer[2,3,4,5,6]. Mean platelet volume (MPV), the most commonly used measure of platelet size, is a surrogate marker of platelet activation[8]. In a small-size sample study, MPV was found to be a prognostic indicator in metastatic colorectal cancer patients treated with bevacizumab-combined chemotherapy[14]. Variables Age (years)
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