Abstract
BackgroundMyelodysplastic syndromes (MDS) is a group of heterogeneous myeloid clonal diseases originating from hematopoietic stem cells. Clinically, elevated mature monocyte in bone marrow is often observed, but its clinical value still remains unclear.MethodsWe retrospectively analyzed a cohort of 216 MDS patients to explore the prognostic value of the percentage of mature monocyte in bone marrow (PMMBM). All patients were divided into elevated PMMBM group and the normal group by 6% PMMBM as the cut-off value.ResultsOur results showed that PMMBM> 6% was associated with inferior overall survival (OS) (P = 0.026) along with higher-risk IPSS-R (P = 0.025) and higher frequency of IDH2 mutation (P = 0.007). Multivariate analyses showed that besides older age (> 60 years) for OS, gender (male) for OS, lower neutrophil count (< 0.8 × 109/L) for OS, higher bone marrow blast percentage (> 5%) for OS and LFS, poorer karyotype for OS, elevated PMMBM was also an independent adverse prognostic factor for OS in MDS (P < 0.0001) but not for LFS (P = 0.736).ConclusionsThese findings indicate that increased PMMBM may assists Revised International Prognostic Scoring System (IPSS-R) to predict a poor outcome and provide a novel evaluation factor for MDS patients especially when their karyotype analyses fail.
Highlights
Myelodysplastic syndromes (MDS) is a group of heterogeneous myeloid clonal diseases originating from hematopoietic stem cells
Unlike MDS, chronic myelomonocytic leukemia (CMML) is characterized by bone marrow (BM) dysplasia and persistent monocytosis, it is placed in a separate category of diseases [12]
Patients characteristics A total of 216 patients of MDS including 99 females and 117 males were identified over a 10-year period with a median age of 61 years
Summary
Myelodysplastic syndromes (MDS) is a group of heterogeneous myeloid clonal diseases originating from hematopoietic stem cells. Myelodysplastic syndromes (MDS), characterized by ineffective hematopoiesis, manifested by morphologic dysplasia in hematopoietic cells and peripheral cytopenia(s), is a group of heterogeneous myeloid clonal diseases originating from hematopoietic stem cells. Unlike MDS, CMML is characterized by bone marrow (BM) dysplasia and persistent monocytosis, it is placed in a separate category of diseases [12]. Later, according to the 2016 revision of the WHO classification, CMML is subgrouped into 3-tiered blast-based categories: CMML-0 (peripheral blood (PB) < 2% and/or BM < 5%); CMML-1 (PB < 5%; BM < 10%) and CMML-2 (PB, 6 to 19%; BM, 10 to 19%) [13]. Previous literatures reported that some patients initially manifest MDS characteristics could progress eventually into CMML [14, 15], a part of which belong to OM-CMML
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
