Abstract

Research has shown that elevations in vaginal innate immune parameters may moderate the association between bacterial vaginosis (BV) and adverse birth outcomes such that high levels are protective. Specifically, elevated levels of IL-8 and IL-1beta have been shown to be inversely correlated with the hydrolytic enzymes sialidase and prolidase. The purpose of this analysis is to describe the relationship between elevated levels of IL-1beta and (a) hydrolytic enzymes and (b) a marker of adaptive immunity (anti-Gvh IgA) in vaginal secretions of BV+ pregnant women.

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