Elevated levels of pre\u03b21-high-density lipoprotein are associated with cholesterol ester transfer protein, the presence and severity of coronary artery disease

Xiao-Min Bu,Jia-Xi Song,Dong-Mei Niu,Jun-Jun Wang,Yun-Long Yuan,Jia Wu

doi:10.1186/s12944-016-0394-1

Abstract

BackgroundPreβ1-high-density lipoprotein (preβ1-HDL), plays an important role in reverse cholesterol transport and exhibits potent risk for coronary artery disease (CAD). However, the association of plasma preβ1-HDL and cholesterol ester transfer protein (CETP) levels in CAD patients and the relationship of preβ1-HDL with extent of CAD are debatable.MethodsPreβ1-HDL and CETP levels were measured by enzymed-linked immunosorbent assay (ELISAs) in 88 acute coronary syndromes (ACS), 79 stable coronary artery disease (SCAD) patients and 85 control subjects. The correlation analyses, multiple linear regression analyses and logistic regression analyses were performed, respectively.ResultsThe preβ1-HDL and CETP levels in ACS patients were significantly higher than those in SCAD patients and both of them were higher than controls’. Preβ1-HDL levels were positively associated with CETP (R = 0.348, P = 0.000), the diameter of stenosis (R = 0.253, P = 0.005), the number of vessel disease (R = 0.274, P = 0.002) and Gensini score (R = 0.227, P = 0.009) in CAD patients. Stepwise multiple linear regression analyses showed that CETP was one of the determinants of preβ1-HDL levels. Logistic regression analysis revealed that elevated preβ1-HDL and CETP were potential risk factors for both ACS and SCAD.ConclusionThe elevated preβ1-HDL levels may change with CETP concentrations in CAD patients and were related to the presence and severity of CAD.

Highlights

Preβ1-high-density lipoprotein, plays an important role in reverse cholesterol transport and exhibits potent risk for coronary artery disease (CAD)
Angiograms of all the CAD patients showed at least 50% stenosis in ≥1 coronary artery. 88 patients with acute coronary syndromes (ACS) included acute myocardial infarction patients and unstable angina (UA) with Braunwald classification II or III, who exhibited the positive cardiac biomarkers result [cardiactroponin I > 0.090 ng/ml], acute ischemic-type chest pain and characteristic electrocardiogram changes. 79 stable coronary artery disease (SCAD) patients with a normal electrocardiogram and documented normal left ventricular contractility, except for possible minor nonspecific ST-T features, had a minimum 1-year history without any cardiac events/procedures suggestive of ACS
Plasma preβ1-high-density lipoprotein (HDL), cholesterol ester transfer protein (CETP) and lipid concentrations in ACS and SCAD patients Compared with control subjects, preβ1-HDL and CETP levels were found significantly increased in both patients with ACS and SCAD

Summary

Introduction

Preβ1-high-density lipoprotein (preβ1-HDL), plays an important role in reverse cholesterol transport and exhibits potent risk for coronary artery disease (CAD). The association of plasma preβ1-HDL and cholesterol ester transfer protein (CETP) levels in CAD patients and the relationship of preβ1-HDL with extent of CAD are debatable. CETP, one of decisive factors that determines highdensity lipoprotein cholesterol (HDL-C), mediates the transfer of CE from HDL to low density lipoprotein (LDL), very low density lipoprotein (VLDL), and an exchange of triglyceride (TG). It relates to particle size, lipid composition and function of lipoprotein [12]. Study has been published to show the relationship of plasma preβ1-HDL and CETP levels in CAD patients. This study was undertaken to investigate the associations of plasma preβ1-HDL and CETP in CAD patients, and to further elucidate the clinical values of preβ1-HDL for evaluating the severity of CAD

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Discussion

Conclusion