Abstract
ObjectivesTo elucidate the association between nerve growth factor (NGF) level and bladder pain syndrome/interstitial cystitis (BPS/IC) by conducting a meta-analysis.MethodsWe conducted a systematic literature search to identify original studies of NGF level in BPS/IC before November 2015. Eligible studies were retrieved via both computer searches and manual review of references. The summary difference estimates between controlled group and BPS/IC group were calculated based on the weighted mean difference (WMD) with its 95 % confidence interval (CI). Sensitivity and publication analyses were performed after the pooled analysis.ResultsMeta-analysis of 10 original studies involving 295 cases and 290 normal controls showed an increased level of urinary NGF in BPS/IC patients (z = 3.08, P = 0.002). The combined WMD was 36.39 (95 % CI 13.27–59.51). There was significant difference between controlled group and BPS/IC patients in the term of NGF/Cr level (WMD = 0.96, 95 % CI 0.58–1.35; z = 4.89, P < 0.01). There was no significant publication bias in the included studies (P for Begg’s test = 0.73, P for egger’s test = 0.13).ConclusionsOur results demonstrated that there was an increased level of NGF in the BPS/IC patients.
Highlights
Bladder pain syndrome/interstitial cystitis (BPS/IC) is one of the most common chronic disorders of urinary bladder (Bosch and Bosch 2014)
Recent studies showed that nerve growth factor (NGF) is a biomarker which could lead to overactive bladder (OAB) and interstitial cystitis or bladder pain (Liu et al 2014; Jiang et al 2013, 2014)
We identified a total of ten studies (Baykara et al 2003; Liu and Kuo 2007; Liu et al 2009, 2010; Boudes et al 2011; Chung et al 2011; Liu and Kuo 2012; Tyagi et al 2012; Jiang et al 2013, 2014) mentioned urinary NGF level in BPS/IC patients according to our above mentioned criteria
Summary
Bladder pain syndrome/interstitial cystitis (BPS/IC) is one of the most common chronic disorders of urinary bladder (Bosch and Bosch 2014). The mainly clinical manifestation is urgency and frequency with or without bladder pain. Some methods for treatment of this disorder have been applied by doctors, while the long-term effect of these methods remains controversy (Diniz et al 2013). And non-invasive diagnosed method has been put forward in recent years. In these methods, the biomarkers in urinary are the hottest topic discussed. Recent studies showed that nerve growth factor (NGF) is a biomarker which could lead to overactive bladder (OAB) and interstitial cystitis or bladder pain (Liu et al 2014; Jiang et al 2013, 2014).
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