Abstract
Anterior pituitary tumors were induced in F344 rats by implants of diethylstilbesterol (DES) for 8 weeks. DES-induced tumors contained 250 times more glandular kallikrein than anterior pituitaries from rats not exposed to estrogen, and 6.6 times more glandular kallikrein than anterior pituitaries from rats exposed to large doses of estrogen for 10 days. DES-induced anterior pituitary tumors in F344 rats arise from lactotroph proliferation. Thus, the results suggest that anterior pituitary glandular kallikrein is associated with lactotrophs.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.