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Abstract
9607 Background: Loss of heterozygosity (LOH) of loci of tumor suppressor genes, such as p16INK4A/p15INK4B, was frequently observed in mouse manmmary tumor virus (MMTV) /neu transgenic mice. The purpose of this study is to investigate the relationship between HER2/neu overexpression and the LOH of the major tumor suppressor genes in human breast carcinoma. Methods: Pairs of primary breast carcinoma tissues and corresponding normal tissues were obtained from 108 Japanese women who underwent surgery in our department. LOH of the loci of two major tumor suppressor genes, p53 and PTEN, was analyzed using the automated sequencer. The expression of HER2/neu in breast cancer tissues was evaluated by automated immunohistochemical method. The relationship between HER2/neu overexpression and the LOH of PTEN and p53 gene was examined. Correlation between LOH of PTEN or p53 locus and other clinico-pathological values was also examined. Results: Overexpression of HER2/neu was observed in 32 samples (29.6 %). LOH of PT...
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