Abstract
Only a few studies have sought to establish whether an underlying coagulation disorder might predispose a patient to thrombosis or coincide with flap failure in the context of free flap surgery. Here, we report a case of both intra- and postoperative arterial anastomotic thromboses and late flap failure due to venous thrombosis after late breast reconstruction with a TRAM flap, in which laboratory evaluation revealed elevated levels of coagulation factor VIII (FVIII). High FVIII concentrations have recently been cited as an independent and dose-dependent risk factor for thromboembolism.
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